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BUB1B, Active

Recombinant human BUB1B (613-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. B12-11G


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Catalog No. Pack Size Price (USD)
B12-11G-05 5 ug $226
B12-11G-10 10 ug $325
B12-11G-BULK BULK Contact Us  


Overview:

BUB1B or budding uninhibited by benzimidazoles 1 homolog beta is involved in spindle checkpoint function and has been localized to the kinetochore. BUB1B plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation (1). BUB1B links the regulation of chromosome-spindle attachment to mitotic checkpoint signaling (2). BUB1B expression during the spindle checkpoint is dependent on residual BUB1B expression and impaired spindle checkpoint function has been found in many forms of cancer. BUB1B is essential for early embryonic development and normal hematopoiesis.


Gene Aliases:

SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta


Genbank Number:


References:


1. Rio Frio. Et.al: Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. New Eng. J. Med. 363: 2628-2637, 2010.

2. Lampson, M. A., Kapoor. et.al: The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nature Cell Biol. 7: 93-98, 2005.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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