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p38 alpha, Unactive

Recombinant full-length human p38alpha was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. M39-14G


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Catalog No. Pack Size Price (USD)
M39-14G-20 20 ug $215
M39-14G-50 50 ug $435
M39-14G-BULK BULK Contact Us  


Overview:

p38α (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response (5).


Gene Aliases:

CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; MAPK14


Genbank Number:


References:


1. Han, J. et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.

2. Ge, B. et al: MAPKK-independent activation of p38-alpha mediated by TAB1-dependent autophosphorylation of p38-alpha. Science 295: 1291-1294, 2002.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~65 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  p38 alpha (K53A), Unactive, M39-16H

  p38 beta, Active, M36-10BG

  p38 delta, Active, M38-10BG

  MEK6, Active, M07-10G


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