p38α (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; MAPK14
1. Han, J. et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.
2. Ge, B. et al: MAPKK-independent activation of p38-alpha mediated by TAB1-dependent autophosphorylation of p38-alpha. Science 295: 1291-1294, 2002.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
FX Theillet et al., Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts Nature Protocols July 2013 10.1038/nprot.2013.083
Deschoemaeker Sofie et al., PHD1 regulates p53-mediated colorectal cancer chemoresistance EMBO Molecular Medicine October 2015 10.15252/emmm.201505492
Choo MK et al., The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential. Science Signaling October 2018 10.1126/scisignal.aau0727
E. Franklin Norah et al., Differential phosphorylation of the phosphoinositide 3-phosphatase MTMR2 regulates its association with early endosomal subtypes Journal of Cell Science February 2013 10.1242/jcs.113928
CM Schonhoff et al., p38 MAPKα and β isoforms differentially regulate plasma membrane localization of MRP2. American Journal of Physiology - Gastrointestinal and Liver Physiology July 2016 10.1152/ajpgi.00005.2016
Selvaraj Nagarathinam et al., Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells Cell Communcation & Signaling February 2015 10.1186/s12964-015-0089-7
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases