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p38 alpha, Active

Recombinant full-length human p38α was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M39-10BG


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Catalog No. Pack Size Price (USD)
M39-10BG-05 5 ug $226
M39-10BG-10 10 ug $325
M39-10BG-BULK BULK Contact Us  


Overview:

p38α (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.


Gene Aliases:

CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; MAPK14


Genbank Number:


References:


1. Han, J. et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.

2. Ge, B. et al: MAPKK-independent activation of p38-alpha mediated by TAB1-dependent autophosphorylation of p38-alpha. Science 295: 1291-1294, 2002.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~67 kDa



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  Anti-p38 alpha, M39-63R

  Anti-p38 beta, M36-63R

  Anti-p38 gamma, M37-63R

  p38 alpha (K53A), Unactive, M39-16H


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