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LATS1, Active

Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. L01-11G


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Catalog No. Pack Size Price (USD)
L01-11G-05 5 ug $226
L01-11G-10 10 ug $325
L01-11G-BULK BULK Contact Us  


Overview:

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding (1). LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments (2).


Gene Aliases:

WARTS; wts


Genbank Number:


References:


1. Tao, W.et.al: Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nature Genet. 21: 177-181, 1999.

2. St. John. et.al: Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nature Genet. 21: 182-186, 1999.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~95 kDa



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle


RELATED PRODUCTS


  LATS2, Active, L02-11G

  LATS2, Unactive, L02-35G


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