Overview:

TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint (1). The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1 (2).

Gene Aliases:

KIAA0137; PKU-beta

Genbank Number:

NM_012290

References:

1. Groth, A. et.al: Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J. 22: 1676-1687, 2003.

2. Krause, D. R. et.al: Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS and Chk1. Oncogene 22: 5927-5937, 2003.