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PDHK2, Active

Recombinant full-length human PDHK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P58-10G


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Catalog No. Pack Size Price (USD)
P58-10G-05 5 ug $226
P58-10G-10 10 ug $325
P58-10G-BULK BULK Contact Us  


Overview:

PDHK2 or Pyruvate Dehydrogenase Kinase 2 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH) (1). PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDHK2 is a primary PPARbeta/delta target gene in humans which underlines the importance of PPAR in the control of metabolism (2). There are two candidate PPAR response elements in the PDHK2 gene.


Gene Aliases:

PDK2


Genbank Number:


References:


1. Gudi, R. et al: Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270: 28989-28994, 1995.

2. Degenhardt, T. et al: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J Mol Biol. 2007 Sep 14;372(2):341-55.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~70 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Metabolic Disorder, Ser/Thr Kinases


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  PDHKtide, P57-58


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