Overview:

PIM3 or pim-3 oncogene belongs to a family of protooncogenes that encode serine/threonine protein kinases (1). Pim-3 expressed in hepatocellular carcinoma development and plays a main role in the proliferation of human hepatoma cell lines (2). Pim-3 also expressed in human pancreatic cancer cell and phosphorylates BAD to block Bad-mediated apoptosis in human pancreatic cancer cell lines (3).

Gene Aliases:

Kid1; MGC27707; MGC37517

Genbank Number:

NM_145478

References:

1. Mikkers, H. et.al: Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Molec. Cell. Biol. 24: 6104-6115, 2004.

2. Fujii, C. et.al: Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int. J. Cancer 114: 209-218, 2005.

3. Li, Y.-Y. et.al: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res. 66: 6741-6747, 2006.