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MSK2, Active

Recombinant full-length mouse MSK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R18-10G


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Catalog No. Pack Size Price (USD)
R18-10G-05 5 ug $226
R18-10G-10 10 ug $325
R18-10G-BULK BULK Contact Us  


Overview:

MSK2 or mitogen- and stress-activated protein kinase-2 is a member of the serine/threonine kinases family that contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. MSK2 is also known as ribosomal protein S6 kinase 4 (RPS6KA4) that are activated by the mitogen-activated protein kinases ERK1, ERK2, and p38.


Gene Aliases:

RPS6KA4; RSK-B; RSKB


Genbank Number:


References:


1. Deak, M. et.al: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17: 4426-4441, 1998.

2. Pierrat, B. et.al: RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38-alpha mitogen-activated protein kinase (p38-alpha-MAPK). J. Biol. Chem. 273: 29661-29671, 1998.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~114 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cellular Stress, Inflammation, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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  RSK1, Active, R15-10G

  RSK2, Active, R17-10G

  RSK3, Active, R16-10G


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