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DDR2, Active

Recombinant human DDR2 (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D06-11BG


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Catalog No. Pack Size Price (USD)
D06-11BG-05 5 ug $226
D06-11BG-10 10 ug $325
D06-11BG-BULK BULK Contact Us  


Overview:

DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain (1) and is thought to be involved in the regulation of cell growth, differentiation, and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung (2).


Gene Aliases:

TKT; NTRKR3; TYRO10


Genbank Number:


References:


1. Karn, T. et al: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Oncogene 8: 3433-3440, 1993.

2. Ferri, N. et al: Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol. 2004 May;164(5):1575-85.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~70 kDa



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, NfkB Pathway, Receptor Tyrosine Kinases


RELATED PRODUCTS


  Modified AXLtide Substrate, A16-58B

  DDR1, Active, D05-11G


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