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STK3, Active

Recombinant full-length human STK3 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. S24-10G


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Catalog No. Pack Size Price (USD)
S24-10G-05 5 ug $226
S24-10G-10 10 ug $325
S24-10G-BULK BULK Contact Us  


Overview:

STK3, also known as MST2, encodes a protein of 491-amino acid which contains an N-terminal catalytic domain characteristic of STKs (1). STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall. RAF1 has been shown to counteract apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). STK3 is a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (2). STK3 activation presumably allows cells to resist unfavorable environmental conditions.


Gene Aliases:

KRS1; MST2; FLJ90748


Genbank Number:


References:


1. Creasy, C L. et al: Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306, 1995.

2. Lee, K K. et al: MST, a physiological caspase substrate, higly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276: 19276-19285, 2001.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~87 kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, Neurobiology, Ser/Thr Kinases


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