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PAK6, Active

Recombinant full-length human PAK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P06-10G


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Catalog No. Pack Size Price (USD)
P06-10G-05 5 ug $226
P06-10G-10 10 ug $325
P06-10G-BULK BULK Contact Us  


Overview:

PAK6 is a Ser/Thr protein kinase that is a member of the PAK (p21-activated kinase) family that are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 is highly expressed in the testis and prostate tissues and interacts with the androgen receptor (AR). In response to androgen, PAK6 cotranslocate into the nucleus with AR (1). PAK6 is weakly expressed in normal prostate epithelium but the expression is increased in primary and metastatic prostate cancer cells and is further increased in tumors that relapse after androgen deprivation therapy (2).


Gene Aliases:

PAK5


Genbank Number:


References:


1. Yang F, et al: Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J. Biol. Chem. 276: 15345-15353, 2001.

2. Kaur R, et al: Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate. 2008 Oct 1;68(14):1510-6.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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