Home   >    Proteins   >   Protein Kinases

TLK2, Active

Recombinant human TLK2 (388-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T11-11G


Shop Online



Catalog No. Pack Size Price (USD)
T11-11G-05 5 ug $226
T11-11G-10 10 ug $325
T11-11G-BULK BULK Contact Us  


Overview:

TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly (1). In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication.


Gene Aliases:

MGC44450; PKU-ALPHA


Genbank Number:


References:


1.Yamakawa, A. et al: cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. Gene,1998; 202 (1-2): 193–201.

2.Sillje, H. H. W. et al: Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J. 18: 5691-5702, 1999.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~67 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Ser/Thr Kinases


RELATED PRODUCTS


  TLK1, Active, T10-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox