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DAPK2, Active

Recombinant human full-length DAPK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D02-10G


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Catalog No. Pack Size Price (USD)
D02-10G-05 5 ug $226
D02-10G-10 10 ug $325
D02-10G-BULK BULK Contact Us  


Overview:

DAPK2 or death-associated protein kinase 2 belongs to a family of proapoptotic Ca(2+)/calmodulin-regulated serine/threonine kinases. Overexpression of DAPK2 induces cell apoptosis. DAPK2 has been shown to be a novel Sp1-dependent target gene for E2F1 and Krüppel-like factor 6 (KLF6) in cell death response (1). Both E2F1 and KLF6 strongly activate the DAPK2 promoter. DAPK2 plays a role in granulopoiesis where it is highly expressed. β-catenin can block anoikis of malignant kidney and intestinal epithelial cells and promote their anchorage-independent growth by down-regulating DAPK2 (2). β-catenin-induced down-regulation of DAPK2 requires the presence of the transcription factor TCF-4.


Gene Aliases:

DRP-1; MGC119312


Genbank Number:


References:


1.Britschgi A. et al: DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function. Oncogene. 2008 Sep 25;27(43):5706-16.

2.Li, H. et al: Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. J Biol Chem. 2009 Jan 23;284(4):2012-22.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~67 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cellular Stress, ERK/MAPK Pathway, Inflammation, Neurobiology, Ser/Thr Kinases


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