Home   >    Proteins   >   Protein Kinases

MYLK3, Active

Recombinant full-length human MYLK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M64-10G


Shop Online



Catalog No. Pack Size Price (USD)
M64-10G-05 5 ug $226
M64-10G-10 10 ug $325
M64-10G-BULK BULK Contact Us  


Overview:

MYLK3 (or myosin light chain kinase 3) plays a key role in rate of cross-bridge recruitment in cardiac myocytes. MYLK3 is upregulated in failing human myocardia and expression of MYLK3 correlates with the pulmonary arterial pressure of patients with heart failure (1). Knockdown of MYLK3 with small interfering RNAs in cultured rat cardiomyocytes decreases Myl2 phosphorylation and impairs epinephrine-induced activation of sarcomere reassembly (2). Recombinant murine MYLK3 shows specificity for Myl2 (Mlc2v) and the phosphorylation is calcium- and calmodulin-dependent.


Gene Aliases:

caMLCK; MLCK, MLCK2, MGC126319, MGC126320


Genbank Number:


References:


1. Chan, J. Y. et al:Identification of cardiac-specific myosin light chain kinase. Circ. Res.2008; 102: 571-580.

2. Seguchi, O. et al: A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J. Clin. Invest. 2007;117: 2812-2824


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~135 kDa



RESEARCH AREAS

Cardiovascular Disease, PKA/PKC Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  MYLK2, Active, M63-10H

  MLCK, Active, M62-11G

  Ca2+/Calmodulin Solution II, 10x, C02-39B

  MRCL3 Peptide, M56-58


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox