Recombinant human ACVR2B (182-488) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A36-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A36-11G-05 | 05 ug | $226 | |
| A36-11G-10 | 10 ug | $325 | |
| A36-11G-BULK | BULK | Contact Us |
Overview:
Activins are dimeric growth and differentiation factors belonging to the TGF-beta superfamily of structurally related signaling proteins that signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors (1). Activin receptor type-2B (ACVR2B) has been shown to regulate muscle growth (2), and is associated with visceral heterotaxy (3). ACVR2B is a transmembrane protein composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain with predicted serine/threonine specificity.
Gene Aliases:
ActR-IIB; ACTRIIB; ACVR2B; MGC116908
Genbank Number:
References :
1. Bondestam, J. et.al: Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. Cytogenet. Cell Genet. 87: 219-220, 1999.
2. Lee, S.-J. et.al: Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc. Nat. Acad. Sci. 102: 18117-18122, 2005.
3. Kosaki R. et al: Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. AM. J. Med. Genet. 82: 70-76, 1999.
Activity:
Sample activity data. For lot-specific data please refer to the specific datasheet.
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Purity:
Sample purity data. For lot-specific data please refer to the specific datasheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. MW 61 kDa
There are no related publications available for this product.
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