Overview:

NEK10 (NIMA Related Kinase 10) is a serine/threonine kinase that is involved in the regulation of the G2/M checkpoint in mitosis. It has unique structure with central catalytic kinase domain flanked by two large regulatory domains (1). NEK10 acts as a positive regulator of ERK1/2 in response to UV irradiation. In mitochondria, NEK10 interacts with GLUD1 and citrate synthase and plays a role in maintaining mitochondrial homeostasis (2). NEK10 also contributes to cilium formation through interaction with PKA and PCM1 and participating in a cAMP dependent pathway [3]. Mutations in NEK10 have been reported in lung cancer and breast cancer (2).

Gene Aliases:

NIMA (Never In Mitosis Gene A) Related Kinase 10

Genbank Number:

NM_152534

References:

1. Meirelles, G.V. et al: Stop Ne(c)king around: How interactomics contributes to functionally characterize Nek family kinases. World J Biol Chem. 5(2):141-60, 2014.

2. Peres de Oliveira, A. et al: NEK10 interactome and depletion reveal new roles in mitochondria. Proteome Sci. 18:4, 2020.

3. Porpora, M. et al: Counterregulation of cAMP-directed kinase activities controls ciliogenesis. Nat Commun. 9(1):1224, 2018.