Overview:

DTYMK belongs to a family of thymidylate kinase proteins (1). DTYMK catalyzes phosphorylation of deoxy-TMP to the corresponding phosphate in the presence of ATP and magnesium. This enzyme is essential for cellular DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs (2). Elevated levels of dTMP have been correlated with poor survival in lung adenocarcinomas hence it is a potential anticancer therapeutic target (3).

Gene Aliases:

CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase

Genbank Number:

NM_012145

References:

1. Su, J.Y. et al: Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. Nucleic Acids Res. 1991; 19(4): 823–827.

2. Huang, S. et al: Human dTMP Kinase: Gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. DNA and Cell Biology. 1994; 13(5):461-471.

3. Liu, Y. et al: Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013; 3(8):870-879.