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CDK9/CyclinT1, Active

Recombinant full-length human CDK9 and CyclinT1 proteins were co-expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C40-18CG


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Catalog No. Pack Size Price (USD)
C40-18CG-05 5 ug $226
C40-18CG-10 10 ug $325
C40-18CG-BULK BULK Contact Us  


Overview:

Cyclin-dependent kinase 9 (Cdk9) is a cdc2-like serine/threonine kinase that associates with cyclin T1 to form a heterodimer. CDK9/Cyclin T1 heterodimer is the main component of the positive transcription elongation factor (P-TEFb) which is critical for the stabilization of the elongation process of RNA polymerase II generated transcripts (1). P-TEFb containing Cdk9 and cyclin T1 is essential for the replication of the human immunodeficiency virus type 1 and type 2 in human cells (2). Cdk9- associated pathway are linked to human malignancies and cardiac hypertrophy (3).


Gene Aliases:

CDK9: CDC2L4, C-2k, TAK, PITALRE CyclinT1: CCNT; CYCT1; HIVE1


Genbank Number:


References:


1. Gaetano, R. et. al: Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. Cell Cycle. 7:23, 3664-3668, 2008.

2. Lin, X. et. al: P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. J Biol Chem. 277:16873-8, 2002.

3. Malumbres, M. et. al: CDK inhibitors in cancer therapy: what is next? Trends Pharmacol Sci. 29:16-21, 2008.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

Approx MW 68 kDa / 110 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Phosphatases


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  CDK9/CyclinT2, Active, C40-18BG


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