Recombinant full-length human WEE1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. W01-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| W01-11G-05 | 5 ug | $226 | |
| W01-11G-10 | 10 ug | $325 | |
| W01-11G-BULK | BULK | Contact Us |
Overview:
WEE1 is a nuclear protein kinase that regulates G2/M transition in response to DNA damage. It catalyzes an inhibitory tyrosine phosphorylation of cyclin-dependent kinase 1-bound cyclin B resulting in G2 cell cycle arrest (1). WEE1 also maintains the proper timing of cell division through phosphorylation of tyrosine15 residues of cyclin-dependent kinases 1 and 2, thereby modulating the activity of both kinases and controlling entry into mitosis and DNA replication during S phase (2).
Gene Aliases:
WEE1hu, WEE1A
Genbank Number:
References:
1. Heald, R. et.al: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase. Cell 74: 463-474, 1993.
2. Parker, L. L. et.al: Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257: 1955-1957, 1992.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
MW 115 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation
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