Overview:

PKCε is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCε is involved in many different cellular functions, such as neuron channel activation , cardioprotection from ischemia (1), heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may control anxiety-like behavior (2).

Gene Aliases:

PRKCE; MGC125656; MGC125657; nPKC-epsilon

Genbank Number:

NM_005400

References:

1. Chen, C H. et al: Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proc. Nat. Acad. Sci. 96: 12784-12789, 1999.

2. Hodge, C W. et al: Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase C-epsilon. J. Clin. Invest. 110: 1003-1010, 2002.