Overview:

Adaptor-associated kinase 1 (AAK1) is a serine/threonine protein kinase of the NAK kinase. Along with GAK, AAK1 regulates clathrin-mediated endocytosis by phosphorylating the μ subunits of both AP-1 and AP-2 trafficking adaptors. The phosphorylation increases the affinity of AP2 for membranes and induces a conformational change enabling cargo recruitment by this adaptor. AAK1 was also shown to play a positive role in regulating the Notch pathway.

Gene Aliases:

KIAA1048

Genbank Number:

BC002695

References:

1. Gupta-Rossi N, et al. The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. J Biol Chem. 286(21):18720-30, 2011.

2. Conner SD, Schmid SL. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol. 156(5):921-9, 2002.