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SRPK2, Active

Recombinant full-length human SRPK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S22-10G


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Catalog No. Pack Size Price (USD)
S22-10G-05 5 ug $226
S22-10G-10 10 ug $325
S22-10G-BULK BULK Contact Us  


Overview:

SRPK2 is a member of the serine/arginine (SR) protein-specific kinase family that are cell cycle-regulated protein kinases which phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing events (1). SRPK2 knock down results in hypophosphorylation of the serine/arginine domain-containing human PRP28 protein thereby destabilizing PRP28 association with the tri-snRNP. RNAi-mediated depletion in HeLa cells showed that SRPK2 is essential for cell viability, and it is required for spliceosomal B complex formation (2).


Gene Aliases:

SFRSK2, FLJ36101


Genbank Number:


References:


1. Wang, H. Y. Et al; SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J. Cell Biol. 140: 737-750, 1998.

2. Mathew, R. et al: Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.Nat Struct Mol Biol. 2008 May;15(5):435-43.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~135kDa



Product Datasheets



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, Ser/Thr Kinases


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