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CHK1, Active

Recombinant full-length human CHK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. C47-10H


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Catalog No. Pack Size Price (USD)
C47-10H-05 5 ug $226
C47-10H-10 10 ug $325
C47-10H-BULK BULK Contact Us  


Overview:

CHK1 is a 56 kDa serine/threonine protein kinase that was originally identified in fission yeast to play a role in activation of the DNA damage checkpoint in the G2 phase of the cell cycle (1). CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia (2).


Gene Aliases:

CHEK1


Genbank Number:


References:


1. Walworth, N. et al: Fission yeast CHK1 protein kinase links the rad checkpoint pathway to cdc2. Nature. 1993 May 27;363(6427):368-71.

2. Walworth, NC. et al: Rad-dependent response of the CHK1-encoded protein kinase at the DNA damage checkpoint. Science. 1996 Jan 19;271(5247):353-6.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~59 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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