MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways (1). Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation (2).
MAP2K2, MKK2, PRKMK2, MAPKK2
1. Shuichan, Xu et al: Differential Regulation of Mitogen-Activated Protein/ERK Kinase (MEK)1 and MEK2 and Activation by a Ras-Independent Mechanism. Mol. Endocrinol. 1997;11 (11): 1618-1625.
2. Louis-François, B, et al: Mek2 Is Dispensable for Mouse Growth and Development. Mol. Cellular Biol. 2003; 23 (14): 4778-4787.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
AS Banks et al., An ERK/Cdk5 axis controls the diabetogenic actions of PPAR[gamma] Nature January 2015 10.1038/nature13887
Joon Kim Dong et al., CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo Carcinogenesis January 2013 10.1093/carcin/bgt015
Hyun Lee Mee et al., Direct targeting of MEK1/2 and RSK2 by silybin induces cell cycle arrest and inhibits melanoma cell growth Cancer Prevention Research February 2013 10.1158/1940-6207.CAPR-12-0425
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases