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MUSK, Active

Recombinant human MUSK (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M60-11G


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Catalog No. Pack Size Price (USD)
M60-11G-05 5 ug $226
M60-11G-10 10 ug $325
M60-11G-BULK BULK Contact Us  


Overview:

MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation (1). MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels (2).


Gene Aliases:

MGC126323, MGC126324


Genbank Number:


References:


1. Okada, K. et al: The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science,. 2006; 312(5781):1802-5

2. Kim, C.H. et al: Regulation of MuSK expression by a novel signaling pathway.J Biol Chem. 2003;278(40):38522-7.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~63 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Neurobiology, Receptor Tyrosine Kinases


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