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HPK1, Active

Recombinant mouse HPK1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M23-11BG


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Catalog No. Pack Size Price (USD)
M23-11BG-05 5 ug $226
M23-11BG-10 10 ug $325
M23-11BG-BULK BULK Contact Us  


Overview:

HPK1 or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. HPK1 is also known as mitogen-activated protein kinase kinase kinase kinase 1(MAP4K1). HPK1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway (1). HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76 (2).


Gene Aliases:

Map4k1, mHPK1, MEKKK1


Genbank Number:


References:


1. Keifer, F. et.al: HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. The EMBO J. 15:7013-7025, 1996.

2. Shui JR. et.al: Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat. Immunol. 8, 84 - 91 (2007).


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~65 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway


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