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SRPK1, Active

Recombinant full-length human SRPK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S21-10G


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Catalog No. Pack Size Price (USD)
S21-10G-05 5 ug $226
S21-10G-10 10 ug $325
S21-10G-BULK BULK Contact Us  


Overview:

SRPK1 is a Ser/Thr protein kinase that has sequence and function similar to SRPK2. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin (1). SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Hence it is believed that SRPK1 plays a key role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors (2).


Gene Aliases:

SFRSK1


Genbank Number:


References:


1. Hayes, G.M. et al: Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas. Cancer Res. 2007;67(5):2072-80.

2. Gui, J.-F. et al: A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369: 678-682, 1994.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~130 kDa



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, Ser/Thr Kinases


RELATED PRODUCTS


  Kinase Dilution Buffer III, K23-09

  MSSK1, Active, S41-10G

  RS Repeat Peptide, R55-58

  SRPIN340, S21-901


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