Recombinant full-length human CDK7 and Cyclin H1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tags.
Catalog No. C36-102H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C36-102H-05 | 5 ug | $226 | |
| C36-102H-10 | 10 ug | $325 | |
| C36-102H-BULK | BULK | Contact Us |
Overview:
CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).
Gene Aliases:
CDK7: CAK1, STK1, CDKN7, p39MO15
Cyclin H1: CCNH, CAK, p34, p37
References:
1. Fisher, R. P.: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.
2. Larochelle, S.: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
CDK7 ~41~43 kDa, and Cyclin H1 ~39 kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Liu Haidan et al., A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases Journal of Biological Chemistry September 2013 10.1074/jbc.M113.464669
J Cairns et al., Bora Downregulation Results in Radioresistance by Promoting Repair of Double Strand Breaks PLoS One March 2015 10.1371/journal.pone.0119208
et al., Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity. European journal of medicinal chemistry October 2020
Cancer, Cell Cycle, Ser/Thr Kinases
Kinase Dilution Buffer III, K23-09
Kinase Assay Buffer I, K01-09
ATP Stock Solution, A50-09
CDK10/CyclinM Protein, C41-34G
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