CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).
CDK7: CAK1, STK1, CDKN7, p39MO15
Cyclin H1: CCNH, CAK, p34, p37
1. Fisher, R. P.: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.
2. Larochelle, S.: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
CDK7 ~41~43 kDa, and Cyclin H1 ~39 kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Liu Haidan et al., A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases Journal of Biological Chemistry September 2013 10.1074/jbc.M113.464669
J Cairns et al., Bora Downregulation Results in Radioresistance by Promoting Repair of Double Strand Breaks PLoS One March 2015 10.1371/journal.pone.0119208
Cancer, Cell Cycle, Ser/Thr Kinases