Recombinant full-length human NEK6 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N08-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N08-10G-05 | 5 ug | $226 | |
| N08-10G-10 | 10 ug | $325 | |
| N08-10G-BULK | BULK | Contact Us |
Overview:
NEK6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA family (1). Nek6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. Nek6 is phosphorylated and activated during M phase of the cell cycle (2). Inhibition of Nek6 function by either overexpression of an inactive Nek6 mutant or elimination of endogenous Nek6 by siRNA arrests cells in M phase and triggers apoptosis.
Gene Aliases:
SID6-1512
Genbank Number:
References:
1. Kandli,M. et al: Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96.
2. Yin, MJ. Et al: The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem. 2003 Dec 26;278(52):52454-60.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~62 kDa
Cancer, Cell Cycle, Ser/Thr Kinases
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Fax: 1-604-232-4601
Jin Jeon Young et al., Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells Journal of Biological Chemistry September 2010 10.1074/jbc.M110.137190 
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