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DYRK4, Active

Recombinant full-length human DYRK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D12-10G


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Catalog No. Pack Size Price (USD)
D12-10G-05 5 ug $226
D12-10G-10 10 ug $325
D12-10G-BULK BULK Contact Us  


Overview:

DYRK4 or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 plays an important role in cell proliferation, survival, and development (1). Northern blot analysis shows DYRK4 is highly expressed in the testis with a very restricted expression to stage VIII postmeiotic spermatids (2). Analysis of a DYRK4 deficient mouse line showed that DYRK4 is dispensable for male fertility, hence suggesting a functional redundancy of some DYRK isoforms during spermiogenesis. DYRK4 protein contains a DYRK homology box in its N-terminal half, followed by a central kinase domain with a YxY loop.


Gene Aliases:

None


Genbank Number:


References:


1. Zhang, D. et.al:DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. Genomics 85: 117-130, 2005.

2. Becker, W. et.al:Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273: 25893-25902, 1998.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~90 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


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