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CDC42BPG (DMPK2), Active

Recombinant human CDC42BPG (1-475) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D17-11G


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Catalog No. Pack Size Price (USD)
D17-11G-05 5 ug $226
D17-11G-10 10 ug $325
D17-11G-BULK BULK Contact Us  


Overview:

Serine/threonine-protein kinase MRCKγ, encoded by CDC42BPG gene, acts as a downstream effector of CDC42 in cytoskeletal reorganization, and contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and MLC2 phosphorylation. It belongs to AGC protein kinase family, DMPK subfamily. It contains an N-terminal kinase domain, followed by a coiled-coil domain, a second coiled-coil domain containing a kinase inhibitory motif (KIM), a variable region, a cysteine-rich domain, a pleckstrin (PLEK; 173570) homology (PH) domain, a citron (605629) homology (CNH) domain, and a C-terminal CDC42 (116952)/RAC (602048) interactive binding (CRIB) domain.


Gene Aliases:

DMPK2; HSMDPKIN; KAPPA-200; MRCKG; MRCKgamma


Genbank Number:


References:


1. Ng, Y. et al: Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. J. Biol. Chem. 279: 34156-34164, 2004.

2. Kedra D. et al: The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 100(5-6):611-9, 1997.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~78 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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