PTEN-induced kinase 1 (PINK1) is a serine/threonine protein kinase that was identified initially in cancer cells as a gene up-regulated by overexpression of the major tumor suppressor, PTEN. It localizes to mitochondria, and regulates multiple aspects of mitochondrial biology. It is implicated in ubiquitin-dependent protein catabolic process to clear damaged mitochondria through selective autophagy (mitophagy). Mutations in the PINK1 gene are linked to early-onset recessive Parkinson disease.
BRPK, PARK6, FLJ27236
1. Unoki M, Nakamura Y. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene. 20:4457-652001, 2001.
2. Aerts L, et al. PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. J Biol Chem. 290:2798-811, 2015.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cellular Stress, Neurobiology