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RIPK4 Protein

Recombinant human RIPK4 (15-426) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R26-35G


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Catalog No. Pack Size Price (USD)
R26-35G-20 20 ug $215
R26-35G-50 50 ug $435
R26-35G-BULK BULK Contact Us  


Overview:

RIPK4 is a serine/threonine protein kinase that interacts with protein kinase C-delta which can also activate NFkappaB and is required for keratinocyte differentiation and it undergoes autophosphorylation. RIPK4 is a direct transcriptional target of p63, a known regulator of stratified epithelial development which acts as a nodal point in the cascade of molecular events that prevent pterygium syndromes (1). RIPK4 functions in the epidermis through PKC specific signaling pathways to regulate differentiation and inflammation (2).


Gene Aliases:

ANKK2, DIK, PKK, RIP4, ANKRD3


Genbank Number:


References:


1. Mitchell, K.et.al: Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.Am. J. Hum. Genet. 90: 69-75, 2012.

2. Rountree, R. B.et.al: RIP4 regulates epidermal differentiation and cutaneous inflammation. J. Invest. Derm. 130: 102-112, 2010.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~57 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases



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