RIPK4 is a serine/threonine protein kinase that interacts with protein kinase C-delta which can also activate NFkappaB and is required for keratinocyte differentiation and it undergoes autophosphorylation. RIPK4 is a direct transcriptional target of p63, a known regulator of stratified epithelial development which acts as a nodal point in the cascade of molecular events that prevent pterygium syndromes (1). RIPK4 functions in the epidermis through PKC specific signaling pathways to regulate differentiation and inflammation (2).
ANKK2, DIK, PKK, RIP4, ANKRD3
1. Mitchell, K.et.al: Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.Am. J. Hum. Genet. 90: 69-75, 2012.
2. Rountree, R. B.et.al: RIP4 regulates epidermal differentiation and cutaneous inflammation. J. Invest. Derm. 130: 102-112, 2010.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases