Overview:

DNAPK is a member of the PI3/PI4-kinase family which encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK), which is involved in DNA nonhomologous end-joining (NHEJ) during DNA double-strand break (DSB) repair and for V(D)J recombination during immune development. The second component of DNA-PK is Ku, which is required for proper activation of PRKDC (1). The initial events in retroviral integration are detected as DNA damage by the host cell, and that completion of the integration process requires the DNA-PK-mediated repair pathway (2).

Gene Aliases:

PRKDC, HYRC, p350, DNA-PK, DNPK1, HYRC1, XRCC7

Genbank Number:

NM_006904

References:

1. Van der Burg, M.et.al: A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J. Clin. Invest. 119: 91-98, 2009.

2. Daniel, R.et.al: A role for DNA-PK in retroviral DNA integration. Science 284: 644-647, 1999.