TSSK6 or testis-specific serine kinase 6 is a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family which is required for postmeiotic chromatin remodeling and male fertility (1). Tssk6-null spermatozoa have impaired DNA condensation. TSSK6 is highly expressed in testis. TSSK6 is present in the equatorial segment of human sperm (2).
CT72; FKSG82; SSTK; TSSK4; TSSK6
1. Spiridonov, N. et.al: Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Molec. Cell. Biol. 25: 4250-4261, 2005.
2. Hao, Z. et.al: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues: a TSSK member is present in the equatorial segment of human sperm. Molec. Hum. Reprod. 10: 433-444, 2004.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cardiovascular Disease, Ser/Thr Kinases