SCYL2 or SCY1-like 2 (S. cerevisiae) is an evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development (1). SCYL2 serves as a regulatory factor for Vpu (viral protein U) which reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction (2).
1. Borner GH. et.al: CVAK104 is a novel regulator of clathrin-mediated SNARE sorting. Traffic. 2007 Jul;8(7):893-903.
2. Miyakawa K. et.al: Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 9;5(245):ra73. doi: 10.1126/scisignal.2003212
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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