Full-length recombinant human RIOK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R05-34G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R05-34G-20 | 20 ug | $215 | |
| R05-34G-50 | 50 ug | $435 | |
| R05-34G-BULK | BULK | Contact Us |
Overview:
RIOK2 or RIO kinase 2 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells which is required late 40S maturation at several distinct steps (1). RIOK2 regulates metaphase-anaphase transition during mitotic progression (2).
Gene Aliases:
FLJ11159
Genbank Number:
References:
1. Zemp I. et.al: Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. J Cell Biol. 2009 Jun 29;185(7):1167-80. doi: 10.1083/jcb.200904048.
2. Liu T. et.al: Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. J Biol Chem. 2011 Oct 21;286(42):36352-60. doi: 10.1074/jbc.M111.250175. Epub 2011 Aug 31.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~106 kDa
AKT/PKB Pathway, Cancer, Ser/Thr Kinases
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et al., RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit PLoS Genetics June 2021 
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