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NEK8, Active

Recombinant human NEK8 (1-322) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N10-11G


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Catalog No. Pack Size Price (USD)
N10-11G-05 5 ug $226
N10-11G-10 10 ug $325
N10-11G-BULK BULK Contact Us  


Overview:

NEK8 or NIMA-related kinase 8 is a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans which may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development (1). NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins (2).


Gene Aliases:

JCK; NEK12A; NPHP9; RHPD2


Genbank Number:


References:


1. Hoff, S.et.al: ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nature Genet. 45: 951-956, 2013

2. Sohara, E.et.al: Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J. Am. Soc. Nephrol. 19: 469-476, 2008.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~66 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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