NEK8, Active
Recombinant human NEK8 (1-322) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N10-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N10-11G-05 | 5 ug | $226 | |
| N10-11G-10 | 10 ug | $325 | |
| N10-11G-BULK | BULK | Contact Us |
Recombinant human NEK8 (1-322) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N10-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N10-11G-05 | 5 ug | $226 | |
| N10-11G-10 | 10 ug | $325 | |
| N10-11G-BULK | BULK | Contact Us |
Overview:
NEK8 or NIMA-related kinase 8 is a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans which may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development (1). NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins (2).
Gene Aliases:
JCK; NEK12A; NPHP9; RHPD2
Genbank Number:
References:
1. Hoff, S.et.al: ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nature Genet. 45: 951-956, 2013
2. Sohara, E.et.al: Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J. Am. Soc. Nephrol. 19: 469-476, 2008.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
Kinase Dilution Buffer III, K23-09
Kinase Assay Buffer I, K01-09
ATP Stock Solution, A50-09
MBP Protein, M42-51N
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