Overview:

MEK5 or MAP2K5 (mitogen-activated protein kinase kinase 5) is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MEK5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MEK5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation (1). The rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer (CRC) (2).

Gene Aliases:

MAP2K5, MAPKK5, MKK5, PRKMK5, SAPKK5; SKK5; HsT17454

Genbank Number:

BC008838

References:

1. Zhou, G.et.al: Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270: 12665-12669, 1995.

2. Diao. D. et.al: Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population. DNA Cell Biol. 2012 Mar; 31(3):342-9. doi: 10.1089/dna.2011.1232. Epub 2011 Aug 23.