CDK20 or cyclin-dependent kinase 20 contains a kinase domain most closely related to the cyclin-dependent protein kinases which may activate cyclin-dependent kinase 2 and is involved in cell growth. CDK20 is a monomeric CAK that specifically phosphorylates CDK2 thr160 and functions as a CDK2-activating kinase. CDK20 is also a novel cyclin-dependent kinase-activating kinase in mammalian cells (1). CDK20 depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner (2).
CCRK; CDCH; PNQLARE; p42; MGC38901
1. Liu, Y.et.al: p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J. Biol. Chem. 279: 4507-4514, 2004.
2. Yang Y. et.al: CRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner. EMBO Rep. 2013 Aug;14(8):741-7
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Krejci P et al., Fibroblast growth factor receptor influences primary cilium length through interaction with intestinal cell kinase Proceedings of the National Academy of Sciences February 2019 10.1073/pnas.1800338116
Feng Hai et al., Cell cycle?related kinase is a direct androgen receptor?regulated gene that drives ?-catenin/T cell factor?dependent hepatocarcinogenesis Journal of Clinical Investigation July 2011 10.1172/JCI45967
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
Cancer, Cell Cycle, Ser/Thr Kinases