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CK1 alpha 1L, Active

Recombinant full-length human CK1 alpha 1L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C75-10G


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Catalog No. Pack Size Price (USD)
C75-10G-05 5 ug $226
C75-10G-10 10 ug $325
C75-10G-BULK BULK Contact Us  


Overview:

CK1alpha1L or casein kinase 1, alpha 1 like is a novel member of the CKI gene family which highlights a critical role for p53 in invasiveness control (1). CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1 and it governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival (2).


Gene Aliases:

CSNK1A1L, CK1A1L, CK1alpha1L, CK1, MGC33182, RP11-532O21.2


Genbank Number:


References:


1. Elyada, E.et.al: CKI-alpha ablation highlights a critical role for p53 in invasiveness control. Nature 470: 409-413, 2011.

2. Bidere, N.et.al: Casein kinase 1-alpha governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. Nature 458: 92-96, 2009.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~64 kDa



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


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