CK1alpha1L or casein kinase 1, alpha 1 like is a novel member of the CKI gene family which highlights a critical role for p53 in invasiveness control (1). CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1 and it governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival (2).
CSNK1A1L, CK1A1L, CK1alpha1L, CK1, MGC33182, RP11-532O21.2
1. Elyada, E.et.al: CKI-alpha ablation highlights a critical role for p53 in invasiveness control. Nature 470: 409-413, 2011.
2. Bidere, N.et.al: Casein kinase 1-alpha governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. Nature 458: 92-96, 2009.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
R Chia et al., Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nature Communications December 2014 10.1038/ncomms6827
I. Dobrikov Mikhail et al., Dynamic Regulation of the Translation Initiation Helicase Complex by Mitogenic Signal Transduction to Eukaryotic Translation Initiation Factor 4G Molecular and Cellular Biology March 2013 10.1128/MCB.01441-12
A. Basta Holly et al., Encephalomyocarditis Virus Leader Is Phosphorylated by CK2 and Syk as a Requirement for Subsequent Phosphorylation of Cellular Nucleoporins Journal of Virology December 2013 10.1128/JVI.03150-13
Mamais Adamantios et al., Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution Journal of Biological Chemistry June 2014 10.1074/jbc.M113.528463
Gao Chenxi et al., Induction of Gsk3β-β-TrCP Interaction Is Required for Late Phase Stabilization of β-catenin in Canonical Wnt Signaling Journal of Biological Chemistry January 2014 10.1074/jbc.M113.532606
Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling