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PI3K (p110 delta (E1021K)/p85 alpha), Active

Recombinant full-length human p110 delta (E1021K) and human p85 alpha were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.
Catalog No. P30-122H


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Catalog No. Pack Size Price (USD)
P30-122H-05 5 ug $259
P30-122H-10 10 ug $380
P30-122H-BULK BULK Contact Us  


Overview:

PI3K (p110 delta /p85 alpha) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring (1). PI3K (p110delta/p85alpha) plays a role in oncogenic transformation and is consistently expressed at a high level in blast cells from AML. PI3K (p110delta/p85alpha) can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that lead to neutrophil polarization, and regulates directional migration, but not random locomotion (2). PI3K (p110delta/p85alpha) signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.


Gene Aliases:

p110 alpha: p110 delta, p85 alpha: PIK3R1, GRB1, p85-ALPHA



References:


1. Vanhaesebroeck, B. et.al: p110-delta, a novel phosphoinositide 3-kinase in leukocytes. Proc. Nat. Acad. Sci. 94: 4330-4335, 1997.

2. Chantry, D. et.al: p110-delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem. 272: 19236-19241,1997.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping :

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

P110 delta: 111 kDa and p85 alpha: 86 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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