Recombinant full-length human PIP4K2B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P76-102BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P76-102BG-05 | 5 ug | $259 | |
P76-102BG-10 | 10 ug | $380 | |
P76-102BG-BULK | BULK | Contact Us |
Overview:
PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase, type II, beta) catalyzes the phosphorylation of phospha-tidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. PIP4K2B is a member of the phosphatidylinositol-5-phosphate 4-kinase family. PIP5K2B interacts specifically with the juxtamembrane region of the p55 TNF receptor and that PIP5K2B activity is increased in mammalian cells by treatment with TNF-alpha (1). PIP5P4KB plays a role in determining insulin sensitivity and adiposity (2).
Gene Aliases:
PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta
Genbank Number:
References:
1. Castellino. et.al: A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 272: 5861-5870, 1997.
2. Lamia, K. A. et.al: Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta -/- mice. Molec. Cell. Biol. 24: 5080-5087, 2004.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
73 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
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