Home   >    Proteins   >   Lipid Kinases

PIK3C3 (Vps34), Active

Recombinant full-length human PIK3C3 (Vps34) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P26-102G


Shop Online



Catalog No. Pack Size Price (USD)
P26-102G-05 5 ug $259
P26-102G-10 10 ug $380
P26-102G-BULK BULK Contact Us  


Overview:

PIK3C3 or phosphoinositide-3-kinase is a member of the PI 3-kinase family that mediates the active diversion of proteins from the secretory pathway to vacuoles. PIK3C3 are involved in both receptor-mediated signal transduction and intracellular trafficking. In yeast, the vps34 gene product is a PI 3-kinase. PIK3C3 has a substrate specificity and ion requirements that are distinct from the other known mammalian PI 3-kinases (1). PIK3C3 mediate catalysis on membranes and suppress futile adenosine triphosphatase cycles. PIK3C3 appears to alternate between a closed cytosolic form and an open form on the membrane (2).


Gene Aliases:

VPS34, hVps34, MGC61518


Genbank Number:


References:


1. Volinia, S. et.al: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14: 3339-3348, 1995.

2. Miller, S. et.al: Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 327: 1638-1642, 2010.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

128 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling


RELATED PRODUCTS


  Lipid Kinase Buffer, L01-09

  MnCl2 Solution, M40-09


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox