Overview:

PIK3C2G belongs to the phosphoinositide 3-kinase (PI3K) family which plays main roles in signaling pathways and involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking (1). PIK3C2G contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs which mediate translocation of proteins to membranes, and may also mediate protein-protein interactions and the N-terminal region of PIK3C2G and the C-terminal C2 domain are required for enzymatic activity (2).

Gene Aliases:

MGC163149; PI3K-C2GAMMA

Genbank Number:

BC130277

References:

1. Rozycka, M.et.al: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2-gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics 54: 569-574, 1998.

2. Misawa, H. et.al: Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem. Biophys. Res. Commun. 244: 531-539, 1998.