Overview:

SENP6 is a mammalian SUMO protease that preferentially disassembles conjugated SUMO2/3 chains. It is found in the nucleoplasm and possess a conserved sequence insertion within the catalytic domain which is absent in the catalytic domains of the other SENP family members (1). SENP6 has been shown to be essential for cell proliferation and cell cycle progression with a prominent role during mitosis (2). SENP6 depleted cells exhibit defects in the spindle assembly and metaphase chromosome congression resulting in mitotic problems and cell death. Thus, SENP6 inhibitors have clinical potential against highly proliferative cancer cells (3).

Gene Aliases:

SUMO-1-specific protease 6, SUSP1, SSP1, KIAA0797

Genbank Number:

NM_015571

References:

1. Choi SJ, et al: (2001) Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J. Biol. Chem. 281, 30669–30677.

2. Mukhopadhyay D, et al: (2010) The SUMO protease SENP6 is essential for inner kinetochore assembly. J Cell Biol. 2010;188(5):681‐692.

3. Liebelt F, et al: (2019) The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation. Nat Commun. 10, 3987.