Overview:

USP35 (ubiquitin carboxyl-terminal hydrolase 35) is a member of the peptidase C19 family of ubiquitin-specific proteases that plays a role in the regulation of mitosis. USP35 deubiquitinates Aurora B, which promotes stability and activates Aurora B. The reaction also antagonizes the APCCDH1-dependent K11-linked ubiquitination of Aurora B. USP35 expression is regulated by FoxM1 as well as Aurora B in the cell cycle (1). USP35 induced by miR let-7a can inhibit cell proliferation by inhibiting NF-κB activation via deubiquitination and stabilization of ABIN-2 protein (2). The miR let-7a-USP35-ABIN-2 pathway can be used as a target for novel cancer therapy.

Gene Aliases:

KIAA1372

Genbank Number:

NM_020798

References:

1. Park, J.Y. et al: USP35 regulates mitotic progression by modulating the stability of Aurora B. Nature Communications 9: 688, 2018.

2. Liu, C. et al: USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2. Oncotarget 6(29): 27891-906, 2015.