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USP7 (N-term), Active

Recombinant human USP7 (25-580a.a.) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U507-381H


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Catalog No. Pack Size Price (USD)
U507-381H-05 5 ug $226
U507-381H-10 10 ug $325
U507-381H-BULK BULK Contact Us  


Overview:

USP7 (ubiquitin carboxyl-terminal hydrolase 7) belongs to the peptidase C19 family and deubiquitinates FOXO4, p53, MDM2, and WASH proteins, and regulates their activities through counteracting ubiquitin ligase activity of proteins such as HDM2 and TRIM27. USP7 was found to contribute to the stabilization and trans-activation of herpesvirus 1 transcriptional protein by strongly interacting with ICP0, a regulatory protein that stimulates lytic infection and the reactivation of viral genome (1). High expression of USP7 was correlated with the proliferation, migration and invasion capacities of hepatocellular carcinoma, indicating that the enzyme may play a role in promoting tumour progression (2).


Gene Aliases:

HAUSP, TEF1


Genbank Number:


References:


1. Boutell, C. et al: Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. Journal of virology 79(19), 12342-54, 2005.

2. Wang, X. et al: Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms. Medical science monitor:international medical journal of experimental and clinical research 24: 1742-1750, 2018


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

68 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


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