Overview:

OUTD7B is a deubiquitinylase that belongs A20 subgroup of ovarian tumor (OUT) protein superfamily. It plays an essential role in inflammation and proliferation pathways. (1) OTUD7B is involved in regulation of the non-canonical NF-NF-κB pathway. (2) Studies suggest role of OUTD7B in cancer and has been shown to promote lung cancer cell proliferation and migration via Akt/VEGF signal pathway. Therefore, strategies to silence OTUD7B in carcinoma tissues may provide insights into developing therapies against lung adenocarcinoma and squamous carcinoma. (3)

Gene Aliases:

CEZANNE, ZA20D1, OTU deubiquitinase 7B

Genbank Number:

NM_020205

References:

1. Cao L. et al. The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-kappaB pathway. J Cell Biochem. 119:1979–91 2018.

2. Hongbo H. et al. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature. 494:371–374, 2013.

3. Dan-dan L. Upregulation of OTUD7B (Cezanne) promotes tumor progression via AKT/VEGF pathway in lung squamous carcinoma and adenocarcinoma. Frontiers in Oncology. 9:862, 2019.