Overview:

CYLD is a cytoplasmic deubiquitinating enzyme, which removes ubiquitin molecules from various signaling proteins, and regulates the activities of many cellular and signaling processes. It plays a role in the regulation of inflammation, immunity, cell cycle progression, spermatogenesis, osteoclastogenesis, ciliogenesis, migration and tumorigenesis. (1) Several signaling pathways, such as the Nuclear Factor-kB (NF-kB), Wnt/β-catenin and c-Jun N-terminal kinase (JNK) pathways, and potentially others have been linked with or regulated by CYLD. (2) Mutations in CYLD gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. (3)

Gene Aliases:

EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2

Genbank Number:

NM_015247

References:

1. Bignell G.R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 25(2):160–165, 2000.

2. Verhoeft, K.R. et al The cylindromatosis (CYLD) gene and head and neck tumorigenesis. Cancers Head Neck. 1: 10, 2016.

3. EntreZ Gene: CYLD cylindromatosis (turban tumor syndrome)